The 1980–81 Scottish Inter-District Championship was a rugby union competition for Scotland's district teams.
This season saw the 28th Scottish Inter-District Championship.

South won the competition with 3 wins.

1980-81 League Table
Results
Round 1
Edinburgh District:

Glasgow District:
North and Midlands:
South:
Round 2
North and Midlands:
Edinburgh District:
Round 3
South:
Edinburgh District:
Glasgow District:
North and Midlands:
Round 4
South:
Glasgow District:
Matches outwith the Championship
Other Scottish matches
Glasgow:
Rest of the West:
South:
Anglo-Scots:
Anglo-Scots:
Edinburgh District:
Junior matches
Glasgow:
South:
South:
Midlands District:
Edinburgh District:
Glasgow District:
South:
Edinburgh District:
Midlands District:
Glasgow District:
Midlands District:
Edinburgh District:
English matches
Durham County 'B':
Edinburgh District 'B':
Yorkshire:
Edinburgh District:
South of Scotland District:
Durham County:
Irish matches
Connacht:
Glasgow District:
Irish Army:
Glasgow District:
Connacht:
South of Scotland District:
Leinster:
South of Scotland District:
Welsh matches
Cardiff District:
North and Midlands:
Mid District:
North and Midlands:
Mid District:
North and Midlands:
Australian matches
South of Scotland District:
Queensland:
Trial matches
Blues:
Whites:





