The 2021 Charlottesville Men's Pro Challenger was a professional tennis tournament played on indoor hard courts. It was the twelfth edition of the tournament which was part of the 2021 ATP Challenger Tour, taking place in Charlottesville, United States from November 1 to 7, 2021.
Singles main-draw entrants
Seeds
1 Rankings are as of 25 October 2021.
Other entrants
The following players received wildcards into the singles main draw: Martin Damm Emilio Nava Jeffrey von der Schulenburg
The following player received entry into the singles main draw using a protected ranking: Peter Polansky
The following players received entry into the singles main draw as alternates: Stefan Kozlov Go Soeda Yosuke Watanuki Wu Tung-lin
The following players received entry from the qualifying draw: Nick Chappell Christian Harrison Denis Kudla Iñaki Montes de la Torre
Champions
Singles
Stefan Kozlov def. Aleksandar Vukic 6–2, 6–3.
Doubles
William Blumberg / Max Schnur def. Treat Huey / Frederik Nielsen 3–6, 6–1, [14–12].