U.S. Route 60 is a major east–west United States highway, traveling from southwestern Arizona to the Atlantic Ocean coast in Virginia. The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as Pacific Avenue, in the city's Oceanfront resort district at the intersection of 5th Street and Winston-Salem Avenue. Its original western terminus was in Springfield, Missouri; it was then extended to Los Angeles, California, but in 1964, it was truncated to end southwest of Brenda, Arizona, at an interchange with Interstate 10 (I-10) after the US 60 highway designation was removed from California. I-10 replaced US 60 from Beaumont, California, to Arizona, and California State Route 60 (SR 60) replaced US 60 from Los Angeles to Beaumont.

Route description

|-

|AZ

|368

|592

|-

|NM

|366

|590

|-

|TX

|225

|362

|-

|OK

|355

|571

|-

|MO

|341

|549

|-

|IL

|1

|2

|-

|KY

|489

|787

|-

|WV

|179

|288

|-

|VA

|302

|486

|-

|Total

|2,655

|4,273

|}

Arizona

The westernmost stretch of US 60, to the California state line, has been replaced by Interstate 10 (I-10). The western terminus of US 60 is near Brenda, from where it travels northeast to Wickenburg. Once US 60 enters Surprise, it carries the name Grand Avenue through the Phoenix metropolitan area before joining I-17 and I-10 in Phoenix for approximately . In Tempe, US 60 exits I-10 and becomes the Superstition Freeway, a significant part of the Phoenix freeway system that serves cities such as Mesa, Gilbert, and Apache Junction. East of the Phoenix area, US 60 bears roughly east-northeast through mountainous areas, passing through Globe, Show Low, and Springerville before entering New Mexico.

U.S. Route 60

New Mexico

US 60 enters New Mexico in Catron County east of Springerville, Arizona. The road makes an arc through Catron County, with the apex at Quemado, avoiding Apache-Sitgreaves National Forest and Escondido Mountain. East of Pie Town, the road crosses the Continental Divide. Between the Divide and Datil, US 60 cuts through Cibola National Forest. In Datil, US 60 serves as the eastern terminus of NM-12.

U.S. Route 60

East of Datil, US 60 traverses the northern end of the Plains of San Augustin, then crosses the county line into Socorro County. The road bisects the Very Large Array complex, and a track used in rearranging the antennas that make up the Array crosses the highway. into the county, the highway passes through Magdalena.

U.S. Route 60

It then enters the county seat of Socorro, where it meets Interstate 25. US 60 heads north, beginning a concurrency with the Interstate.

US 60 splits off from I-25 near Bernardo, about north of Socorro. It turns back eastward, rising through Abo Pass at the southern end of the Manzano Mountains before crossing into Torrance County and passing through Mountainair, where it intersects NM-55. After passing through Willard, it sets out across the Pedernal Hills. In Encino, it begins a concurrency with US-285. Just after crossing into Guadalupe County, US-54 joins the concurrency. The three highways pass through Vaughn and then go their separate ways, with US 285 heading southeast towards the direction of Roswell, US 54 heading northeast towards both Santa Rosa and Interstate 40, and US 60 heading east towards Clovis.

US 60 angles southeast toward Yeso, entering De Baca County en route. Curving back towards the east, the road enters Fort Sumner, the county seat, later. Just west of town, it serves as the northern terminus of NM-20, and in Fort Sumner proper, it begins a concurrency with US-84, which will persist for the remainder of the routes' miles in New Mexico. East of town the two highways encounter NM-212, a spur to Fort Sumner State Monument, and NM 252 in Taiban.

US 60/84 passes through Tolar near the De Baca–Roosevelt County line. The two routes do not stay in Roosevelt County for long, however, proceeding into Curry County west of Melrose. The highways pass through Melrose, St. Vrain, and Grier before widening out to a four-lane highway as they approach Clovis, the Curry County seat. In Clovis, the home of Cannon Air Force Base, the highways meet up with US-70, which joins the concurrency. The three highways proceed through Texico, and then cross the state line near Farwell, Texas.