Cristina Calderón (May 24, 1928 – February 16, 2022) was a Chilean writer. She was born in Puerto Williams, Navarino Island. She was the last living full-blooded Yaghan person after the death of her 84 year-old sister Úrsula in 2005. She was also the last native speaker of the Yaghan language.
Calderón was honored as the Illustrious Daughter of the Magallanes Region and Chilean Antarctica. She was also recognized by the National Council of Culture and the Arts as a Living Human Treasure by UNESCO in 2003.
Calderón died on February 16, 2022 in Punta Arenas, Chile from COVID-19 at the age of 93.