Route 22, or Highway 22, can refer to:
International
European route E22
Argentina
National Route 22
Australia
Great Western Highway, Parramatta Road
Austria
Donauufer Autobahn
Canada
Alberta Highway 22
Alberta Highway 22X
British Columbia Highway 22
Manitoba Highway 22
Nova Scotia Trunk 22
Ontario Highway 22
Prince Edward Island Route 22
Saskatchewan Highway 22
China
G22 Expressway
Costa Rica
National Route 22
Czech Republic
I/22 Highway; Czech: Silnice I/22
Finland
Finnish national road 22
Iceland
Route 22 (Iceland)
India
National Highway 22 (India)
Iran
Road 22
Ireland
N22 road (Ireland)
Israel
Highway 22 (Israel)
Italy
Autostrada A22
Japan
Japan National Route 22
Korea, South
National Route 22
Gukjido 22
New Zealand
State Highway 22
Paraguay
National Route 22
United Kingdom
British A22 (Eastbourne-London) M22 motorway (Northern Ireland) A22 road (Northern Ireland)
United States
Interstate 22
U.S. Route 22
Alabama State Route 22
Arkansas Highway 22
California State Route 22
County Route A22 (California) County Route J22 (California) County Route S22 (California) Colorado State Highway 22 Connecticut Route 22 Florida State Road 22 County Road 22 (Gulf County, Florida) County Road 22 (Liberty County, Florida) County Road 22 (Wakulla County, Florida) Georgia State Route 22 Hawaii Route 22 (former) Idaho State Highway 22 Illinois Route 22 Indiana State Road 22 Iowa Highway 22 K-22 (Kansas highway) Kentucky Route 22 Louisiana Highway 22 Maine State Route 22 Maryland Route 22 Massachusetts Route 22 M-22 (Michigan highway) Minnesota State Highway 22 County Road 22 (Chisago County, Minnesota) County Road 22 (Hennepin County, Minnesota) County Road 22 (Washington County, Minnesota) Missouri Route 22 Nebraska Highway 22 Nevada State Route 22 (former) New Jersey Route 22 (former) County Route C22 (Bergen County, New Jersey) County Route 22 (Monmouth County, New Jersey) County Route 22 (Ocean County, New Jersey) New Mexico State Road 22 New York State Route 22 New York State Route 22B County Route 22 (Chautauqua County, New York) County Route 22 (Chenango County, New York) County Route 22 (Columbia County, New York) County Route 22 (Dutchess County, New York) County Route 22 (Genesee County, New York) County Route 22 (Greene County, New York) County Route 22 (Oneida County, New York) County Route 22 (Orange County, New York) County Route 22 (Oswego County, New York) County Route 22 (Otsego County, New York) County Route 22 (Putnam County, New York) County Route 22 (Saratoga County, New York) County Route 22 (Schoharie County, New York) County Route 22 (Schuyler County, New York) County Route 22 (St. Lawrence County, New York) County Route 22 (Suffolk County, New York) County Route 22 (Ulster County, New York) North Carolina Highway 22 North Dakota Highway 22 Ohio State Route 22 (1923-1927) (former) Oklahoma State Highway 22 Oregon Route 22 Pennsylvania Route 22 (1920s) (former) South Carolina Highway 22 South Dakota Highway 22 Tennessee State Route 22 Texas State Highway 22 Texas State Highway Spur 22 Farm to Market Road 22 Texas Park Road 22 Utah State Route 22 Virginia State Route 22 Virginia State Route 22 (1918-1933) (former) Washington State Route 22 Primary State Highway 22 (Washington) (former) Wisconsin Highway 22 Wyoming Highway 22