The following is a list of cases of sarcoma of the nose and throat treated by cultures of erysipelas, or Coley’s fluid, the physicians in charge, and the time the patient is living after treatment at the time of the report in Dr. Coley’s paper, in 1898:
(a) A spindle-celled sarcoma of the neck and tonsils, inoculated culture—patient living six years after.
(b) A spindle-celled sarcoma of the parotid; it had been extirpated twice previous to treatment—patient living one year after.
(c) A sarcoma (mixed celled) of the parotid—patient living three years after. The foregoing under Dr. Coley’s care.
(d) A spindle-celled sarcoma of the palate and pharynx extending to the vocal cords—Dr. W. B. Johnson—living four and three-quarter years.
(e) A round-celled sarcoma of antrum, pharynx, and neck—Dr. L. L. McArthur—child aged five years, weight gained from 37 to 69 pounds—later, fatal recurrence.
(f) A round-celled sarcoma of parotid, size of the fist—Czerny of Heidelberg—living over a year.
(g) A spindle-celled sarcoma of the parotid—Horace Packard—living two and three-quarter years.
(h) A round-celled sarcoma of the neck—H. Montague—slight return in six months.
(i) A recurrent sarcoma of the neck and tonsil—J. O. Roe—six months after treatment died of erysipelas.
The mode of administration is cumulative. The injection is of course to be made under the most thorough antiseptic principles attainable. It is by far preferable to make the injection into the growth itself, although, if this is impossible, it may be introduced into the nearest accessible point, but in the latter case the dosage needs to be doubled.
As a rule one-half drop is the initial dose, and this is increased one-half drop each succeeding day until toleration is reached. This is evidenced by the natural reactionary fever rising to 102° or 103° F. In such case the following dose should be the same as the preceding, and if it should again go so high reduce the next dose one-half drop. The dose is increased in this manner until the maximum is attained. When applied to the neoplasm itself 8 drops is the full dose, or if elsewhere, double that amount, 16 drops.
This last amount is to be continued daily until the tumor has disappeared.