The 2022 Challenger de Santiago was a professional tennis tournament played on clay courts. It was the 16th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Santiago, Chile between 7 and 13 March 2022.
Singles main-draw entrants
Seeds
1 Rankings are as of 28 February 2022.
Other entrants
The following players received wildcards into the singles main draw: Ignacio Becerra Diego Fernández Flores Daniel Antonio Núñez
The following players received entry from the qualifying draw: Hernán Casanova Evan Furness Facundo Juárez Paul Jubb Matteo Martineau Juan Bautista Torres
The following player received entry as a lucky loser: Daniel Dutra da Silva
Champions
Singles
Hugo Dellien def. Alejandro Tabilo 6–3, 4–6, 6–4.
Doubles
Diego Hidalgo / Cristian Rodríguez def. Pedro Cachin / Facundo Mena 6–4, 6–4.