The 2021 Orlando Open was a professional tennis tournament played on hard courts. It was the third edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Orlando, United States between 12 and 18 April 2021.
Singles main-draw entrants
Seeds
1 Rankings are as of 5 April 2021.
Other entrants
The following players received wildcards into the singles main draw: Christian Harrison Zane Khan Aleksandar Kovacevic
The following players received entry from the qualifying draw: Altuğ Çelikbilek Martin Damm Roberto Quiroz Tim van Rijthoven
The following player received entry as a lucky loser: Kevin King
Champions
Singles
Jenson Brooksby def. Denis Kudla 6–3, 6–3.
Doubles
Mitchell Krueger / Jack Sock def. Christian Harrison / Dennis Novikov 4–6, 7–5, [13–11].