Isaac was one of the Hundred Associates, and after 1628 was their naval commander. In the spring of 1629, the company, hearing that Kirk's expedition was about to set out from England, prepared a fleet, loaded with supplies for the suffering colonists at Quebec. Orders were given that some of the vessels should sail directly from Dieppe or La Rochelle for Canada, leaving the rest to go later, under Razilly. These orders were neglected, so that, instead of reaching Quebec by the end of May, and thus affording timely aid to Champlain, the ships waited for Razilly--whose commission for Canada was, however, revoked upon the conclusion of the peace of Susa (April 24, 1629), and he was instead sent to Morocco. The vessels finally set sail from La Rochelle, but were delayed by bad weather, thus failing to reach Quebec before its capture by Kirk. The ship commanded by De Caen was taken by the English; that belonging to the Jesuits was wrecked off Canso (see vol. iv., doc. xix.); and those under Desdames and Joubert made their way back to France. In the spring of 1630, another expedition was fitted out by the Company of New France, under Razilly's command, for the recapture of Canada; but it was not despatched thither, owing to the promise of Charles I. to restore Quebec to France--an agreement that was, however, not carried into effect until 1632, because of Louis's delay in paying the dowry that he had promised with Henrietta Maria, Charles's queen. Finally, in that year, De Caen was sent to occupy Quebec for his king. At the same time, Razilly was commissioned to "put the Company of New France in possession of Port Royal"--for which purpose he was given an armed ship named "Espérance en Dieu," and the sum of 10,000 livres; he was also to take with him three Capuchin missionaries. The document authorizing this enterprise was signed by Richelieu March 27, 1632, two days before the treaty of St. Germain-en-Laye. Razilly's formal commission to receive Port Royal from the English bears date of May 10 in the same year. These documents are given by Margry, in _MSS. rel. Nouv. France_, vol. i., pp. 85, 110.
Razilly was appointed governor of Acadia, D'Aulnay and Charles de la Tour being his lieutenants; he also obtained from the Company of New France (May 29, 1632) a concession at St. Croix river and bay, 12 by 20 leagues in extent. He established his seat of government at La Hêve. In January, 1635, was formed an association--headed by Isaac and Claude de Razilly, and Cardinal Richelieu--to colonize Port Royal and La Hêve. Isaac de Razilly died in November of that year, and was succeeded by D'Aulnay as governor of Acadia. Claude de Razilly inherited his brother's estates, which, with his own interests in Acadia, he subsequently transferred to D'Aulnay. Harrisse says (_Notes_, p. 57): "He seems to have died in poverty, about the year 1666--at least, we have reason to suppose this, from the petition in verse addressed to the king in 1667, by his sister Marie, a celebrated poetess known as 'Calliope' [1621-1704] to whom Louis XIV. granted a pension of 2,000 livres, in consideration of the straitened circumstances to which she had been reduced by her brother's losses (Titon du Tillet, _Parnasse François_, Paris, 1732, fol., p. 487)."