The 2022 George Mason Patriots baseball team represented George Mason University during the 2022 NCAA Division I baseball season. The Patriots played their home games at Spuhler Field as a member of the Atlantic 10 Conference. They were led by head coach Bill Brown, in his 41st season at Mason.
George Mason finished the season with a 22–33 record and a 13–11 record in Atlantic 10 play. They earned a berth into the 2022 Atlantic 10 Conference baseball tournament, where they were eliminated in game 8 by Richmond.
Previous season
The 2021 team finished the season with a 14–29 (7–17 Atlantic 10) record, and finished in last place in the South Division of the Atlantic 10. They did not earn a berth into the 2021 Atlantic 10 Conference baseball tournament nor the 2021 NCAA Division I baseball tournament.
Preseason
Coaches poll
The Atlantic 10 baseball coaches' poll was released on February 15, 2022. George Mason was picked to finish tenth in the Atlantic 10.