Danville Main Street Historic District is a national historic district located at Danville, Hendricks County, Indiana. The district encompasses 42 contributing buildings and 2 contributing structures in the central business district of Danville. The district developed between about 1865 and 1960 and includes notable examples of Italianate, Classical Revival, Beaux-Arts, and Tudor Revival style architecture. Located in the district is the separately listed Hendricks County Jail and Sheriff's Residence. Other notable buildings include the Hall Block (c. 1900), Danville Public Library (1902-1903), Hendricks County Courthouse (1915), and Danville Post Office (1936).
It was added to the National Register of Historic Places in 2010.