Dust Mohammad Rural District () is in the Central District of Hirmand County, Sistan and Baluchestan province, Iran. Its capital is the city of Dust Mohammad.
At the National Census of 2006, its population (as a part of the former Hirmand District of Zabol County) was 20,788 in 4,264 households. There were 17,972 inhabitants in 4,173 households at the following census of 2011. By the time of the census, Hirmand District had been separated from Zabol County to form Hirmand County. It was then divided into the Central and Qorqori Districts. At the most recent census of 2016, the population of the rural district was 16,742 in 4,669 households. The largest of its 103 villages was Deh-e Khamr, with 1,119 people.