The Loy Kirksey House is a historic house in rural Clark County, Arkansas. It is located on the south side of Still Creek Road (County Road 59) east of the hamlet of Fendley. This single-story dog trot house was built in stages, beginning with a single log pen that probably predates the American Civil War. Around 1895 this structure was expanded to form the dog-trot by William Kirksey. The only significant alteration since then is the replacement of the original chimney in the mid-20th century with the present brick one. The property also includes two single-story log barns built in the early decades of the 20th century.
The house was listed on the National Register of Historic Places in 1992.