The 2022–23 DePaul Blue Demons men's basketball team represented DePaul University during the 2022–23 NCAA Division I men's basketball season. They were led by second-year head coach Tony Stubblefield and played their home games at Wintrust Arena in Chicago, Illinois as members of the Big East Conference. The Demons finished the season 10–23, 3–17 in Big East play to finish in tenth place. They defeated Seton Hall in the first round of the Big East tournament before losing to Xavier in the quarterfinals.
On January 10, 2023, DePaul defeated Villanova for the first time since 2008, snapping a 22-game losing streak to the Wildcats over 15 years.
Previous season
The Blue Demons finished the 2021–22 season 15–16, 6–14 in Big East play to finish in 10th place. They lost in the first round of the Big East tournament to St. John's.