The 2021–22 LEN Euro League Women is the 34th edition of the major competition for European women's water polo clubs. It started on 18 November 2021.
Qualification round
Group A
Dynamo Uralochka 15–11 ANO Glyfada
CSS Verona 26–10 ASA Tel Aviv
CN Terrassa 10–8 CSS Verona
ANO Glyfada 18–2 ASA Tel Aviv
CN Terrassa 27–5 ASA Tel Aviv
Dynamo Uralochka 12–9 CN Terrassa
Dynamo Uralochka 12–9 CSS Verona
ANO Glyfada 12–11 CSS Verona
Dynamo Uralochka 29–8 ASA Tel Aviv
CN Terrassa 9–5 ANO Glyfada
Group B
Lille 27–3 Sirens
SIS Roma 20–7 ZVL–Tetteroo
Mediterrrani 10–8 Ferencvarosi
SIS Roma 15–10 Mediterrrani
Ferencvarosi 11–8 Lille
ZVL–Tetteroo 25–2 Sirens
Ferencvarosi 13–7 ZVL–Tetteroo
SIS Roma 31–4 Sirens
Mediterrrani 12–9 Lille
SIS Roma 8–4 Ferencvarosi
Mediterrrani 28–5 Sirens
Lille 13–9 ZVL–Tetteroo
Ferencvarosi 28–2 Sirens
SIS Roma 16–12 Lille
Mediterrrani 11–10 ZVL–Tetteroo
Group C
Plebiscito Padova 9–8 CN Mataró
NC Vouliagmeni 13–5 BVSC-Zuglo
Spandau 13–13 Nice
CN Mataró 20–6 Spandau
BVSC-Zuglo 12–6 Nice
Plebiscito Padova 7–7 NC Vouliagmeni
Plebiscito Padova 11–6 BVSC-Zuglo
CN Mataró 19–7 Nice
NC Vouliagmeni 15–13 Spandau
Plebiscito Padova 16–4 Spandau
CN Mataró 15–8 BVSC-Zuglo
NC Vouliagmeni 15–6 Nice
CN Mataró 8–6 NC Vouliagmeni
Plebiscito Padova 15–8 Nice
BVSC-Zuglo 12–11 Spandau
Group D
CN Sabadell 34–3 Pacense
Ekipe Orizzonte 15–14 Ethnikos Piraeus
Ethnikos Piraeus 25–4 Pacense
CN Sabadell 15–8 Ethnikos Piraeus
Ekipe Orizzonte 21–6 Ol. Kosice
Ol. Kosice 16–9 Pacense
Ekipe Orizzonte 25–2 Pacense
CN Sabadell 31–5 Ol. Kosice
CN Sabadell 11–7 Ekipe Orizzonte
Ethnikos Piraeus 23–4 Ol. Kosice
Preliminary round
Source:
Group E
CN Sabadell 11–6 Ferencvarosi
Dunaujvaros 12–8 CN Mataró
CN Mataró 14–5 Ferencvarosi
CN Sabadell 10–7 Dunaujvaros
Dunaujvaros 13–10 Ferencvarosi
CN Mataró 10–9 CN Sabadell
Group F
Olympiacos Piraeus 11–5 CN Terrassa
Ethnikos Piraeus 14–5 SIS Roma
Olympiacos Piraeus 15–8 SIS Roma
Ethnikos Piraeus 8–7 CN Terrassa
CN Terrassa 12–7 SIS Roma
Olympiacos Piraeus 9–5 Ethnikos Piraeus
Group G
UVSE 11–5 NC Vouliagmeni
Dynamo Uralochka 15–8 Ekipe Orizzonte
NC Vouliagmeni 9–7 Ekipe Orizzonte
UVSE 13–12 Dynamo Uralochka
Dynamo Uralochka 12–11 NC Vouliagmeni
UVSE 9–9 Ekipe Orizzonte
Group H
Plebiscito Padova 10–8 Mediterrrani
Kinef Kirishi 16–12 ANO Glyfada
Plebiscito Padova 14–10 ANO Glyfada
Kinef Kirishi 9–9 Mediterrrani
Mediterrrani 17–12 ANO Glyfada
Plebiscito Padova 7–7 Kinef Kirishi
Quarterfinals
Sources:
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05/02/2022 Olympiacos Piraeus 14–9 Dunaujvaros
26/02/2022 Dunaujvaros 7–10 Olympiacos Piraeus
20/02/2022 Plebiscito Padova 8–11 Dynamo Uralochka
03/03/2022 Dynamo Uralochka W.O. Plebiscito Padova
05/02/2022 Kinef Kirishi 8–7 UVSE
26/02/2022 UVSE7–11 Kinef Kirishi
05/02/2022 Ethnikos Piraeus 8–13 CN Sabadell
26/02/2022 CN Sabadell 8–6 Ethnikos Piraeus
Kinef Kirishi and Dynamo Uralochka were disqualified. Padova and UVSE replaced them in the F4.