Cameron Downtown Historic District is a national historic district located at Cameron, Marshall County, West Virginia. It encompasses 27 contributing buildings in the commercial core developed after a severe fire in 1895 which destroyed much of the downtown area. They are large 2-4 story brick buildings reflecting the Classical Revival and Colonial Revival styles. Notable buildings include the Masonic Lodge 17 (c. 1900), Romine Building/Moose Lodge 758 (c. 1900), First Presbyterian Church (1907), First United Methodist Church (1894), Hotel Main (c. 1896-1897), Finlayson's 5 & 10/ Senior Citizens Building (c. 1896), Flatiron Building (1896), First Christian Church of Cameron (1896), and Old B&O Freight Station (1878).
It was listed on the National Register of Historic Places in 1998.