van Wyk is a common Afrikaans surname, derived from the Dutch Van Wijk. Notable people with the surname include:

Abraham Erasmus van Wyk (born 1952), South African taxonomist

Ben-Erik van Wyk (born 1956), South African taxonomist

Arnold van Wyk (1916–1983), South African composer

Christopher van Wyk (1957–2014), South African writer

Coenie van Wyk (born 1988), South African rugby union player

D. J. Van Wyk (died 1902), a Member of the Cape House of Assembly for Riverdale

Diaan van Wyk (born 1981), South African cricketer

Ferdi van Wyk, South African officer

Hermanus van Wyk (1835–1905), Namibian tribal chief

Inke van Wyk (born 1971), South African field hockey player

Janine van Wyk (born 1987), South African association football player

Juandre van Wyk (born 1989), South African cricketer

Kruger van Wyk (born 1980), New Zealand cricketer

Lenert van Wyk (born 1989), South African cricketer

Morne van Wyk (born 1979), South African cricketer

N. P. van Wyk Louw (1906–1970), South African poet and playwright

Ruben Van Wyk (born 1976), Namibian footballer

Surnames of Dutch origin

Afrikaans-language surnames

Van Wyk