Lipscomb is a surname. Notable people with the surname include:
A. W. G. Lipscomb, Superintendent of the Aborigines Welfare Board in New South Wales, Australia from 1940 Andrew A. Lipscomb (1816–1890), American clergyman and educator Bob Lipscomb (1837–1895), English cricketer David Lipscomb (1831–1917), preacher and founder of Lipscomb University Eugene Lipscomb (1931–1963), American football player Frank Lipscomb (1863–1951), English cricketer George Lipscomb (1773–1846), English physician and county historian of Buckinghamshire Glenard P. Lipscomb (1915–1970), US politician and submarine namesake Guy Lipscomb (1917–2009), industrialist and watercolorist from Columbia, South Carolina Kalija Lipscomb (born 1997), American football player Lila Lipscomb, who appears in the movie Fahrenheit 9/11 Mance Lipscomb (1895–1976), American blues musician Michael Lipscomb (born 1983), American musician Nathaniel Lipscomb (1931–1961), American serial killer Oscar Hugh Lipscomb (1931–2020), American Roman Catholic Archbishop Oswald Lipscomb (1872–1930), American carpenter Suzannah Lipscomb (born 1978), English historian William Lipscomb (1919–2011), American inorganic chemist