Sisco or Sisko may refer to:
Sisco, Haute-Corse, a commune in Corsica, France
Sisco (stream), a coastal stream in Corsica, France
Sisco, Washington, a community in the United States
Persons with the surname
Andrew Sisco (born 1983), American baseball pitcher
Chance Sisco (born 1995), American baseball catcher
Jack Sisco (1904–1983), American football player, coach, and official
Kristina Sisco (born 1982), American actress
Fictional characters
Karen Sisco, a United States Marshal created by novelist Elmore Leonard, also appearing in a television series and the film Out of Sight. From the television series, Star Trek: Deep Space Nine: Benjamin Sisko Jake Sisko Jennifer Sisko Joseph Sisko
See also
Sisqó (born 1978), American R&B singer, songwriter, record producer, dancer and actor Gene Siskel, American film critic and journalist