John Michael Bishop (born February 22, 1936) is an American immunologist and microbiologist. He shared the 1989 Nobel Prize in Physiology or Medicine with Harold Varmus and was co-winner of 1984 Alfred P. Sloan Prize. He currently serves as an active faculty member at the University of California, San Francisco.
Bishop is best known for his Nobel-winning work on retroviral oncogenes. Working with Varmus in the 1980s, he discovered the first human oncogene, c-Src.
Their findings showed how malignant tumors are formed from changes to the normal genes of a cell. These changes can be produced by viruses, by radiation, or by exposure to some chemicals.