First Baptist Church, originally known as Lexington African Baptist Church, is a historic Baptist church building in the city of Lexington, Virginia, United States. It was built between 1894 and 1896, and is a large brick church on a limestone basement in the Gothic Revival style. It has a front gable roof, round and lancet-arch stained glass windows, and towers at its two front corners. The right hand tower has a belfry and spire. The interior consists of a barrel-vaulted auditorium with a gallery on turned posts and the basement has classroom and meeting spaces. Historically First Baptist played a central role in the life of Lexington's African-American community.
It was listed on the National Register of Historic Places in 2006.