On October 18, 1849, the Dominican minister of foreign affairs in a note to the French consul, stated that "the present situation of the country and the barbarous wars with the Haitians, obliged him to beg, in the name of his government, that the government of France give a definite solution to the important matter of the protectorate; and if the decision of France should unfortunately be in the negative, that it at least be not deferred too long to prevent him from addressing himself to the special representative of the United States, who had just arrived." The United States was mentioned as a bogey, for when France declined, the Dominican government stated that it could not consider the negative as final and appealed to the French sentiments of humanity. In 1854 another strong attempt was made to secure a Spanish protectorate. Neither France nor Spain was anxious to annex a hornet's nest, and Spain was fearful that any uprising against her authority would find an echo in Cuba and Porto Rico. In 1855 negotiations were opened with General William L. Cazneau, special agent of President Pierce, for the lease of the Samana peninsula to the United States, and in the following year Captain (later Major-General) George B. McClellan, of the United States Army, made an examination of Samana Bay. Nothing came of this matter owing to opposition by foreign powers and the fall of the Santana government. Most annexation negotiations were secret, as the opponents of the party that happened to be in power never failed to stigmatize them as treasonable.
The fear of American influence was one of the reasons given by the Haitian emperor Soulouque for his invasion of 1855, and for an invitation issued by him in 1858 to the Dominican people, calling upon them to return to the Haitian flag. It had its influence on the Spanish government also, which began to look more kindly upon annexation propositions and agreed to furnish arms, ammunition and military instructors to Santo Domingo. In 1860 Santana addressed himself directly to the Queen of Spain, and proposed a closer union. Bases for annexation were drawn up, founded "on the free and spontaneous wish of the Dominican people." Santana was careful to win over the local military chiefs to his ideas. His opponents vainly combatted the proposition from Curaçao and from Haiti, which was now a republic again.