The 2020–21 Macedonian Football Cup was the 29th season of North Macedonia's football knockout competition. This edition did not have a defending champions due to the interruption of the previous edition due to the COVID-19 pandemic.
Competition calendar
Source:
First round
The draw was held on 15 September 2020. The semi-finalists from the previous season (Akademija Pandev, Bregalnica, Shkëndija, and Struga) received byes. Matches were played on 22 and 23 September 2020.
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|colspan="3" style="background-color:#97DEFF" align=center|22 September 2020
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|colspan="3" style="background-color:#97DEFF" align=center|23 September 2020
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Second round
The draw was held on 29 September 2020. The matches were played on 21 October 2020.
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|colspan="3" style="background-color:#97DEFF" align=center|21 October 2020
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Quarter-finals
The draw was held on 27 October 2020. The matches were played on 25 November 2020.
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|colspan="3" style="background-color:#97DEFF" align=center|25 November 2020
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Semi-finals
The draw was held on 16 March 2021. The matches were played on 6 and 7 April 2021.