Sistan Rural District () is in Sistan District of Kuhpayeh County, Isfahan province, Iran. It is administered from the city of Sejzi.
At the National Census of 2006, its population (as a part of the former Kuhpayeh District of Isfahan County) was 1,248 in 344 households. There were 1,437 inhabitants in 432 households at the following census of 2011. At the most recent census of 2016, the population of the rural district was 1,076 in 312 households. The largest of its 44 villages was Vartun, with 576 people.
The district was separated from Isfahan County in July 2021, elevated to the status of Kuhpayeh County, and divided into Sistan and Tudeshk Districts, each with two rural districts. The city of Kuhpayeh was designated as the county's capital.