The 2000 Arab Cup Winners' Cup was the 11th edition of the Arab Cup Winners' Cup held in Riyadh, Saudi Arabia between 8 – 22 November 2000. The teams represented Arab nations from Africa and Asia. Al-Hilal from Saudi Arabia won the final against Al-Nassr from the same country for the first time.
Qualifying round
Al-Hilal (the hosts) and Al-Ittihad (the holders) qualified automatically.
Zone 1 (Gulf Area) Qualifying tournament held in Dubai, United Arab Emirates. Representatives of Bahrain and Oman withdrew.
|-
!colspan=3|Day 1
|-
!colspan=3|Day 2
|-
!colspan=3|Day 3
Al-Wasl & Al-Arabi advanced to the final tournament. However Al-Wasl withdrew, Al-Rayyan admitted instead.
Zone 2 (Red Sea) Qualifying tournament held in Cairo, Egypt. Al-Wehda of Yemen withdrew.
|-
!colspan=3|Day 1
|-
!colspan=3|Day 2
|-
!colspan=3|Day 3
Zone 3 (North Africa) Libya representative withdrew. USM Annaba, Algeria and SCC Mohammédia, Morocco qualified.
Zone 4 (East Region) Qualifying tournament held in Amman, Jordan.
|-
!colspan=3|Day 1
|-
!colspan=3|Day 2
|-
!colspan=3|Day 3
Al-Wehdat & Jableh SC advanced to the final tournament.