The Mazepa family () was a noble Ruthenian/Ukrainian family. Their origin can be traced back to 1544, when the Ukrainian szlachtych Mykola Mazepa-Koledynski was given a khutor (farmstead) Kamyanets (which later grew to become the village of Mazepyntsi) by King Sigismund I for his duty.
Mykola Mazepa-Koledynski had two grandsons: Fedir Mykhaylovych Mazepa – a Cossack otaman. He fought against the Poles together with Hryhory Loboda, Severyn Nalyvaiko & Krzysztof Kosiński. Later he was caught and together with Severyn Nalyvaiko was executed in Warsaw. Stepan-Adam Mazepa. His spouse Maryna Mazepa (died 1707) of Mokiev descent became a nun and later hegumenia of the in Kiev. They had a son, Ivan, and a daughter, who later married Andrew Voynorovskiy.
Notable members
Ivan Mazepa (1639–1709) – Hetman of Zaporizhian Host (1687–1709) Andriy Voynarovsky (1689-1740) - nephew and heir of Ivan Mazepa, member of the Zaporozhian Army Isaak Mazepa (1884–1952) – Prime minister of Ukraine Anna Politkovskaya (1958–2006)