The Perry-Cooper House is a historic home located at Salisbury, Wicomico County, Maryland, United States. It is a three-story frame dwelling topped with a French mansard roof that was built about 1880. It features a central tower, with a bowed entrance on the first floor and a nine-foot-high Palladian window on the second. It was the residence of one of Salisbury's well-known civic leaders, Thomas Perry, whose family occupied the house from 1897 until 1950.
The Perry-Cooper House was listed on the National Register of Historic Places in 1977.