Daniil Medvedev defeated Jannik Sinner in the final, 7–5, 6–3 to win the men's singles tennis title at the 2023 Miami Open. It was his fifth career ATP Tour Masters 1000 title, fourth title of 2023, and 19th career title overall. He became only the eighth man to win a fifth Masters title.
Carlos Alcaraz was the defending champion, but lost in the semifinals to Sinner.
Novak Djokovic regained the ATP No. 1 ranking from Alcaraz at the end of the tournament, despite having been unable to enter the United States due to being unvaccinated for COVID-19.
Seeds
All seeds received a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Section 3
Section 4
Bottom half
Section 5
Section 6
Section 7
Section 8
Seeded players
The following are the seeded players. Seedings are based on ATP rankings as of March 20, 2023. Rankings and points before are as of March 20, 2023.
† The player did not qualify for the main draw in 2022. Points from his 19th best result will be deducted instead.
Withdrawn players
The following players would have been seeded, but withdrew before the tournament began.