George Neale Jr. House, also known as the Pence Building, is a historic home located at Parkersburg, Wood County, West Virginia. Built in 1840, it is a two-story structure with a stone foundation and walls of handmade orange-red brick in the Greek Revival style. The house was converted into law and real estate offices in the 1880s. Additions to the original building were built in 1958 and 1973.
George Neale, Jr., had previously had a house built on nearby Blennerhassett Island in 1833. That building, which was also constructed with handmade bricks, is today a ruin.
It was listed on the National Register of Historic Places in 1980.