The 2022 AON Open Challenger was a professional tennis tournament played on clay courts. It was the eighteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Genoa, Italy between 19 and 25 September 2022.
Singles main-draw entrants
Seeds
1 Rankings are as of 12 September 2022.
Other entrants
The following players received wildcards into the singles main draw: Federico Arnaboldi Gianmarco Ferrari Albert Ramos Viñolas
The following player received entry into the singles main draw using a protected ranking: Sebastian Ofner
The following players received entry into the singles main draw as alternates: Adrian Andreev Lukas Neumayer
The following players received entry from the qualifying draw: Andrey Chepelev Matteo Gigante Sandro Kopp Martin Krumich Matteo Martineau Gabriele Piraino
The following player received entry as a lucky loser: Oscar José Gutierrez
Champions
Singles
Thiago Monteiro def. Andrea Pellegrino 6–1, 7–6(7–2).
Doubles
Dustin Brown / Andrea Vavassori def. Roman Jebavý / Adam Pavlásek 6–2, 6–2.