Arrow poisons were well known to the Greeks and their word "toxicon" signified a poisonous substance into which the arrow-"toxon" was dipped. Homer alludes to the use of poisoned arrows in the "Odyssey," and Ovid mentions the bile and blood of vipers as being employed to poison weapons. The Scythians and the tribes of the Caucasus were reputed to use Viper poison mixed with the serum of human blood that had decomposed. The Celts and the Gauls, according to Pliny, dipped their arrow-heads in hellebore juice; and down to the seventh century we find poisoned weapons were commonly used in Europe.
During the Middle Ages until the sixteenth century, the poisoned dagger or sword formed the favourite weapon of the assassin, and the preparation of the blade for this purpose was brought almost to a fine art in Spain. It is recorded that Lorenzo de Medici was stabbed with a poisoned dagger; and the Duke de Biscaglia, the second husband of the famous Lucrezia Borgia, nearly fell a victim to the assassin's knife on the steps of St. Peter's.
Of all other methods employed by poisoners, the administration of the lethal dose through the medium of food or drink seems ever to have been the favourite. The poisoned wine or cake recurs with a somewhat monotonous frequency in the history of the poisoner, from the earliest times down to the present day. Women especially seem to have been attracted by this mode of poisoning, a fact probably due to their control and direction of domestic matters, which rendered the introduction of a poisonous substance into food or drink an easy matter. Occasionally they have fallen victims to their own evil designs, as instanced in the case of Rosamond the wife of Helmichis, King of Lombardy, in the year 575. Wishing to rid herself of her husband, she gave him a cup of poisoned wine on coming from his bath. The king drank part of it, and suspecting its nature from the strange effect it produced, he insisted she should drink the remainder, with the result that both died shortly afterwards.
The Hindoos have an ingenious method of using powdered glass as a lethal agent, either by mixing it with sherbet or some kind of food. In such cases the substance acts by its irritant action on the stomach or intestines, while at the same time, if successful, no trace of poison can be discovered in the bodily organs.