Chake Chake District () is one of two administrative districts of Pemba South Region in Tanzania. The district covers an area of . The district is comparable in size to the land area of American Samoa. The district has a water border to the east and west by the Indian Ocean. The district is bordered to the south by Mkoani District and the north by Wete District of Pemba North Region. The district seat (capital) is the town of Chake-Chake. According to the 2012 census, the district has a total population of 97,249.
Administrative subdivisions
As of 2012, Chake Chake District was administratively divided into 31 wards.