The 2022 Purdue Fort Wayne Mastodons baseball team was a baseball team that represented Purdue University Fort Wayne in the 2022 NCAA Division I baseball season. The Mastodons were members of the Horizon League and played their home games at Mastodon Field in Fort Wayne, Indiana. They were led by third-year head coach Doug Schreiber.
Previous season
In their first season in the Horizon League, the Mastodons finished the 2022 NCAA Division I baseball season 11–35 overall (8–28 conference) and seventh place in the conference standings, as the season was limited to only 40 games, and an increase of conference games from 30 to 36 due to the COVID-19 pandemic.
Roster
Schedule
! style="" | Regular season
|- valign="top"
|- align="center" bgcolor="#ffcccc" | 1 || February 18 || at Georgia State || Georgia State Baseball Complex • Atlanta, Georgia || 2–13 || Treadway (1–0) || J. Miller (0–1) || Lutz (1) || 372 || 0–1 || – |- align="center" bgcolor="#ffcccc" | 2 || February 19 || at Georgia State || Georgia State Baseball Complex • Atlanta, Georgia || 2–12 || Dawson (1–0) || Deany (0–1) || None || 395 || 0–2 || – |- align="center" bgcolor="#ffcccc" | 3 || February 19 || at Georgia State || Georgia State Baseball Complex • Atlanta, Georgia || 5–6 || Clark (1–0) || Myer (0–1) || None || 395 || 0–3 || – |- align="center" bgcolor="#ffcccc" | 4 || February 20 || at Georgia State || Georgia State Baseball Complex • Atlanta, Georgia || 7–8 || Reddick (1–0) || Martens (0–1) || Jones (1) || 385 || 0–4 || – |- align="center" bgcolor="#ffcccc" | 5 || February 25 || at || James W. Totman Stadium • Riverside, California || 2–4 || Culpepper (2–0) || Miller (0–2) || Finnel (1) || 372 || 0–5 || – |- align="center" bgcolor="#ffcccc" | 6 || February 26 || at California Baptist || James W. Totman Stadium • Riverside, California || 5–23 || Necochea (1–0) || Wilson (0–1) || None || 336 || 0–6 || – |- align="center" bgcolor="#ffcccc" | 7 || February 26 || at California Baptist || James W. Totman Stadium • Riverside, California || 3–5 || Villalobos (1–0) || Myer (0–2) || None || 334 || 0–7 || – |- align="center" bgcolor="#ffcccc" | 8 || February 27 || at California Baptist || James W. Totman Stadium • Riverside, California || 1–11 || Silvas (2–0) || Martens (0–2) || None || 289 || 0–8 || – |-