The belief in the prophylactic power of tobacco was, however, very generally held. When Mr. Samuel Pepys on June 7, 1665, for the first time saw several houses marked with the ominous red cross, and the words "Lord, have mercy upon us" chalked upon the doors, he felt so ill at ease that he was obliged to buy some roll tobacco to smell and chew. There is nothing to show that Pepys even smoked, which considering his proficiency in the arts of good-fellowship, is perhaps a little surprising. Defoe, in his fictitious but graphic "Journal of the Plague Year in London," says that the sexton of one of the London parishes, who personally handled a large number of the victims, never had the distemper at all, but lived about twenty years after it, and was sexton of the parish to the time of his death. This man, according to Defoe, "never used any preservative against the infection other than holding garlic and rue in his mouth, and smoking tobacco."
When excavations were in progress early in 1901, preparatory to the construction of Kingsway and Aldwych, they included the removal of bodies from the burying-grounds of St. Clement Danes and St. Mary-le-Strand; and among the bones were found a couple of the curious tobacco-pipes called "plague-pipes," because they are supposed to have been used as a protection against infection by those whose office it was to bury the dead. These pipes have been dug up from time to time in numbers so large that one antiquary, Mr. H. Syer Cuming, has ventured to infer that "almost every person who ventured from home invoked the protection of tobacco."
These seventeenth-century pipes were largely made in Holland of pipe-clay imported from England--to the disgust and loss of English pipe-makers. In 1663 the Company of Tobacco-Pipe Makers petitioned Parliament "to forbid the export of tobacco pipe clay, since by the manufacture of pipes in Holland their trade is much damaged." Further, they asked for "the confirmation of their charter of government so as to empower them to regulate abuses, as many persons engage in the trade without licence." The Company's request was granted; but in the next year they again found it necessary to come to Parliament, showing "the great improvement in their trade since their incorporation, 17 James I, and their threatened ruin because cooks, bakers, and ale-house keepers and others make pipes, but so unskilfully that they are brought into disesteem; they request to be comprehended in the Statute of Labourers of 5 Elizabeth, so that none may follow the trade who have not been apprentices seven years."