Vito Santarsiero (born 2 March 1955 in Potenza) is an Italian politician.
Former member of the Christian Democracy, he joined the Italian People's Party in 1994 and then The Daisy in 2002. He has been a member of the Democratic Party since 2007.
He was elected President of the Province of Potenza at the 1999 elections and served as Mayor of Potenza for two terms from 2004 to 2014. Santarsiero also served as President of the Regional Council of Basilicata from April 2018 to April 2019.