The 2021–22 Egyptian Second Division was the 42nd edition of the Egyptian Second Division, the top Egyptian semi-professional level for football clubs, since its establishment in 1977. The season started on 30 September 2021 and concluded on 4 June 2022. Fixtures for the 2021–22 season were announced on 12 September 2021.
Aswan, El Dakhleya and Haras El Hodoud won Group A, Group B and Group C respectively and secured the promotion to the 2022–23 Egyptian Premier League.
Format
The league consists of 48 teams divided into 3 groups of 16 teams each, with each group covering different parts of Egypt: Group A for teams from Upper Egypt and eastern governorates. Group B for teams from Greater Cairo, and central and north-eastern governorates. Group C for teams from Alexandria and northern governorates.
The top team from each group earns promotion to the next season of the Egyptian Premier League, while the bottom 4 teams from each group get relegated to the Egyptian Third Division.
Teams
Team name followed with ↓ indicates the team was relegated from the 2020–21 Egyptian Premier League. Team name followed with ↑ indicates the team was promoted from the 2020–21 Egyptian Third Division.