Bonne Terre Depot, also known as the Mississippi River and Bonne Terre Railway Depot, is a historic train station located at Bonne Terre, St. Francois County, Missouri. It was built in 1909 by the Mississippi River and Bonne Terre Railway, and is a 2 1/2-story, Queen Anne / Stick style frame building on an ashlar foundation. It has a hipped roof with dormers and features a round, conical-roofed tower and encircling verandah with bell-cast profile. The building has been renovated as a bed and breakfast inn.
It was added to the National Register of Historic Places in 1984.