In the interior, great pillars of a soft dark-red tint support the high groined arches and the effect is severe and impressive. The altar at the head of the nave is beautifully inlaid with wrought silver and is surmounted by the coat of arms of Spain placed there by order of Charles V, a relic of Spanish days which was hidden away while the Haitians were in possession of the city. On the altar platform a marble slab indicates the place where the bones of Columbus were found in 1877, another slab the former location of the remains taken to Cuba in 1795 as the remains of Columbus, and still another the resting place of Louis Columbus, the grandson of the Discoverer. At the end of the nave, near the entrance door, is the airy marble monument beneath which is guarded the casket that contains the remains of the Discoverer of America.
The cathedral like the other churches is made more interesting by the ancient epitaphs on slabs in the pavement and walls, marking the burial places of persons famous in the history of the island. In one of the lateral chapels, which belonged to the Bastidas family, the resting place of Bishop Bastidas, who in the early days was bishop in Venezuela, Porto Rico and Santo Domingo, is marked by a large marble recumbant figure of a bishop and the chapel is therefore known as "the chapel of the stone bishop." Nearby is the tomb of his father, that Rodrigo de Bastidas who was imprisoned by Bobadilla, and an epitaph full of abbreviations which reads:
"Here lies the very magnificent Sir Don Rodrigo de Bastidas, first Adelantado and Governor and Captain-General of Santa Marta, who in the year 1502 discovered Terra-firma by order of the Catholic Sovereigns from Cape Vela to Darien: he died March 28, 1527."
"Here lies the virtuous, Christian and religious lady Doña Isabel Rodrigo de Romera, native of the noble town of Carmona, who was wife of the Adelantado Don Rodrigo de Bastidas and mother of the most reverend Bishop of San Juan, Don Rodrigo de Bastidas. She died September 15, 1533. May she rest in peace."
"I believe that my Redeemer lived and that on the judgment day I shall be resurrected."
In another chapel is a slab ten feet long with an elaborate coat of arms, surmounted by a helmet with flowing plumes, and having an inscription reading: