At length he resolved to leave Laura and Avignon forever; and instead of plunging into solitude, to seek the wiser resource of travel and society. Laura saw him depart with regret. When he went to take leave of her, he found her surrounded by a circle of her ladies. Her mien was dejected; a cloud overcast her face, whose expression seemed to say, "Who takes my faithful friend from me?" Petrarch was struck to the heart by a sad presentiment: the emotion was mutual; they both seemed to feel that they should never meet again.
Petrarch departed. The plague, which had been extending its ravages over Asia, entered Europe. It spread far and wide: nearly one half the population of the world became its prey. Petrarch saw thousands die around him, and he trembled for his friends. He heard that it was at Avignon. A thousand sad presentiments haunted his mind. At last the fatal truth reached him, Laura was dead! By a singular coincidence, she died on the anniversary of the day when he first saw her. She was taken ill on the third of April, and languished but three days. As soon as the symptoms of the plague declared themselves, she prepared to die: she made her will, which is dated on the third of April, and received the sacraments of the church. On the sixth she died, surrounded by her friends and the noble ladies of Avignon, who braved the dangers of infection to attend on one so lovely and so beloved. On the evening of the same day on which she died, she was interred in the chapel of the Cross which her husband had lately built in the church of the Minor Friars at Avignon.
Her tomb was discovered and opened in 1533, in the presence of Francis the First, whose celebrated stanzas on the occasion are well known.
Of the fame which, even in her lifetime, love and poetical adoration of Petrarch had thrown around his Laura, a curious instance is given which will characterize the manners of the age. When Charles of Luxembourg (afterwards Emperor) was at Avignon, a grand fête was given, in his honor, at which all the noblesse were present. He desired that Petrarch's Laura should be pointed out to him; and when she was introduced, he made a sign with his hand that the other ladies present should fall back; then going up to Laura, and for a moment contemplating her with interest, he kissed her respectively on the forehead and on the eyelids.