The 2022 Columbus Challenger II was a professional tennis tournament played on indoor hard courts. It was the twelfth edition of the men's tournament which was part of the 2022 ATP Challenger Tour. It took place in Columbus, United States between September 19 and 25, 2022.
Singles main draw entrants
Seeds
1 Rankings are as of September 12, 2022.
Other entrants
The following players received entry into the singles main draw as wildcards: Justin Boulais Cannon Kingsley James Tracy
The following players received entry into the singles main draw as alternates: Nick Chappell Ezekiel Clark Omni Kumar
The following players received entry from the qualifying draw: Robert Cash Ryan Harrison Patrick Kypson Naoki Nakagawa Nathan Ponwith James Trotter
The following player received entry as a lucky loser: Strong Kirchheimer
Champions
Singles
Jordan Thompson def. Emilio Gómez 7–6(8–6), 6–2.
Doubles
Julian Cash / Henry Patten def. Charles Broom / Constantin Frantzen 6–2, 7–5.