Velyka Lepetykha Raion () was one of the 18 administrative raions (a district) of Kherson Oblast in southern Ukraine. Its administrative center was located in the urban-type settlement of Velyka Lepetykha. The raion was abolished on 18 July 2020 as part of the administrative reform of Ukraine, which reduced the number of raions of Kherson Oblast to five. The area of Velyka Lepetykha Raion was merged into Kakhovka Raion. The last estimate of the raion population was
At the time of disestablishment, the raion consisted of two hromadas: Rubanivka rural hromada with the administration in the selo of Rubanivka; Velyka Lepetykha settlement hromada with the administration in Velyka Lepetykha.