The 2021 Garden Open was a professional tennis tournament played on clay courts. It was the twelfth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Rome, Italy between 19 and 25 April 2021.
Singles main-draw entrants
Seeds
1 Rankings as of 12 April 2021.
Other entrants
The following players received wildcards into the singles main draw: Stefano Napolitano Andrea Pellegrino Giulio Zeppieri
The following player received entry into the singles main draw using a protected ranking: Thanasi Kokkinakis
The following player received entry into the singles main draw as a special exempt: Mathias Bourgue
The following players received entry into the singles main draw as alternates: Andrea Collarini Borna Gojo
The following players received entry from the qualifying draw: Flavio Cobolli Vít Kopřiva Tristan Lamasine Alex Molčan
Champions
Singles
Andrea Pellegrino def. Hugo Gaston 3–6, 6–2, 6–1.
Doubles
Sadio Doumbia / Fabien Reboul def. Paolo Lorenzi / Juan Pablo Varillas 7–6(7–5), 7–5.