In the thirtieth year of his reign Thothmes lead an expedition against the Rutennu, the people of Northern Syria. In this campaign he attacked and captured Kadesh, a strong fortress in the valley of Orontes, and the capital town of the Rutennu. The king pushed his conquests into Mesopotamia, and occupied the strong fortress of Carchemish, on the banks of the Euphrates. He then led his conquering troops northwards to the sources of the Tigris and the Euphrates, so that the kings of Damascus, Nineveh, and Assur became his vassals, and paid tribute to Egypt.
Punt or Arabia was also subdued, and in Africa his conquests extended to Cush or Ethiopia. His fleet of ships sailed triumphantly over the waters of the Black Sea. Thus Thothmes ruled over lands extending from the mountains of Caucasus to the shores of the Indian Ocean, and from the Libyan Desert to the great river Tigris.
"Besides distinguishing himself as a warrior and as a record writer, Thothmes III. was one of the greatest of Egyptian builders and patrons of art. The great temple of Ammon at Thebes was the special object of his fostering care, and he began his career of builder and restorer by repairing the damages which his sister Hatasu had inflicted on that glorious edifice to gratify her dislike of her brother Thothmes II., and her father Thothmes I. Statues of Thothmes I. and his father Amenophis, which Hatasu had thrown down, were re-erected by Thothmes III. before the southern propylæa of the temple in the first year of his independent reign. The central sanctuary which Usertesen I. had built in common stone, was next replaced by the present granite edifice, under the directions of the young prince, who then proceeded to build in rear of the old temple a magnificent hall or pillared chamber of dimensions previously unknown in Egypt. This edifice was an oblong square one hundred and forty-three feet long by fifty-five feet wide, or nearly half as large again as the nave of Canterbury Cathedral. The whole of this apartment was roofed in with slabs of solid stone; two rows of circular pillars thirty feet in height supported the central part, dividing it into three avenues, while on each side of the pillars was a row of square piers, still further extending the width of the chamber, and breaking it up into five long vistas. In connection with this noble hall, on three sides of it, north, east, and south, Thothmes erected further chambers and corridors, one of the former situated towards the south containing the 'Great Table of Karnak.'