The 2018 Jacksonville State Gamecocks football team represented Jacksonville State University as a member of the Ohio Valley Conference (OVC) during the 2018 NCAA Division I FCS football season. Led by fifth-year head coach John Grass, the Gamecocks compiled an overall record of 9–4, with a mark of 7–1 conference play, winning the OVC title for the fifth consecutive season. Jacksonville State received the OVC's automatic bid to the NCAA Division I Football Championship playoff marking the program's sixth straight trip to the FCS playoffs. The Gamecocks defeated East Tennessee State in the first round before losing to Maine in the second round. The team played home games at Burgess–Snow Field at JSU Stadium in Jacksonville, Alabama.
Preseason
OVC media poll
On July 20, 2018, the media covering the OVC released their preseason poll with the Gamecocks predicted to win the OVC championship. On July 23, the OVC released their coaches poll with the Gamecocks also predicted to become OVC champions.
Preseason All-OVC team
The Gamecocks had six players selected to the preseason all-OVC team. Defensive lineman Randy Roberinson was also selected as the preseason defensive player of the year.