The 2021 Tallahassee Tennis Challenger was a professional tennis tournament played on green clay courts. It was the 21st edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Tallahassee, Florida, United States between 19 and 25 April 2021.
Singles main-draw entrants
Seeds
1 Rankings as of April 12, 2021.
Other entrants
The following players received wildcards into the singles main draw: Martin Damm Ryan Harrison Toby Kodat
The following players received entry into the singles main draw as alternates: Thomaz Bellucci Pedro Sakamoto
The following players received entry from the qualifying draw: Filip Jianu Alexander Ritschard Alex Rybakov Agustín Velotti
The following player received entry as a lucky loser: Donald Young
Champions
Singles
Jenson Brooksby def. Bjorn Fratangelo 6–3, 4–6, 6–3.
Doubles
Orlando Luz / Rafael Matos def. Sekou Bangoura / Donald Young 7–6(7–2), 6–2.