The 2021 Quito Challenger was a professional tennis tournament played on clay courts. It was the 22nd edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Quito, Ecuador between 13 and 19 September 2021.
Singles main-draw entrants
Seeds
1 Rankings are as of 30 August 2021.
Other entrants
The following players received wildcards into the singles main draw: Álvaro Guillén Meza Antonio Cayetano March Gian Carlos Rodríguez
The following players received entry from the qualifying draw: Luca Castelnuovo Alexis Gautier Alejandro Gómez Christian Langmo
Champions
Singles
Facundo Mena def. Gonzalo Lama 6–4, 6–4.
Doubles
Alejandro Gómez / Thiago Agustín Tirante def. Adrián Menéndez Maceiras / Mario Vilella Martínez 7–5, 6–7(5–7), [10–8].