The 2022 Women's Six Nations Championship was the 21st Women's Six Nations Championship, an annual rugby union competition contested by the national teams of England, France, Ireland, Italy, Scotland and Wales. England were the defending champions, having won a COVID shortened version of the tournament in 2021. There was no limit on the number of players each team may call up to play in the competition.
Note: Number of caps are indicated as of the first match of the tournament (26 March 2022).
England
Head coach: Simon Middleton
On 7 March Simon Middleton announced England's 40 player squad for the tournament
France
Head coach: Annick Hayraud
On 14 March 2022 Annick Hayraud announced their 35 player squad for the tournament.
On 29 March Céline Ferer, Maïlys Traoré and Safi N'Diaye were all added to the squad to face Ireland
Caroline Boujard was added to the squad prior to the fourth round match against Wales.
Ireland
Head coach: Greg McWilliams
On 3 March 2022 Greg McWilliams announced his 38 player squad for the tournament.
On 21 March Nichola Fryday was named captain for the tournament.
On 19 April 2022 Laura Feely, Laura Sheehan, Mary Healy, Shannon Touhey, Sene Naoupu, Niamh Byrne and Alice O'Dowd were all called up to the squad.
Italy
Head coach: Andrea Di Giandomenico
On 14 March 2022 Andrea Di Giandomenico announced his squad for the championship.
Due to a COVID-19 outbreak in the Italy squad Federica Cipolla was added to the squad for the Round 3 game against Ireland.
Scotland
Head coach: Bryan Easson
On 15 March 2022 Scotland head coach Bryan Easson announced his team for the 2022 championship.
Panashe Muzambe was added to the squad prior to Scotland's second-round game against Wales.
Wales
Head coach: Ioan Cunningham
On 17 March 2022 Cunningham named their 37 player squad for the championship.