The 2021 Argentina Open was a men's tennis tournament played on outdoor clay courts. It was the 24th edition of the ATP Buenos Aires event and part of the ATP Tour 250 series of the 2021 ATP Tour. It took place in Buenos Aires, Argentina, from 1–7 March 2021.
Finals
Singles
Diego Schwartzman def. Francisco Cerúndolo, 6–1, 6–2.
Doubles
Tomislav Brkić / Nikola Ćaćić def. Ariel Behar / Gonzalo Escobar, 6–3, 7–5.
Points and prize money
Point distribution
Prize money
*per team
Singles main draw entrants
Seeds
1 Rankings are as of February 22, 2021
Other entrants
The following players received wildcards into the singles main draw: Thiago Agustín Tirante Facundo Díaz Acosta Holger Vitus Nødskov Rune
The following players received special exemptions into the singles main draw: Facundo Bagnis Juan Manuel Cerúndolo
The following players received entry from the qualifying draw: Francisco Cerúndolo Lukáš Klein Jaume Munar Sumit Nagal
Withdrawals
Before the tournament
Pablo Cuevas → replaced by Gianluca Mager
Pedro Martínez → replaced by Andrej Martin
Guido Pella → replaced by Roberto Carballés Baena
Doubles main draw entrants
Seeds
1 Rankings are as of February 22, 2021
Other entrants
The following pairs received wildcards into the doubles main draw: Francisco Cerúndolo / Federico Coria Facundo Díaz Acosta / Thiago Agustín Tirante
Withdrawals
Before the tournament
Marco Cecchinato / Guido Pella → replaced by Roberto Carballes Baena / Salvatore Caruso Pablo Cuevas / Oliver Marach → replaced by Oliver Marach / Luis David Martínez Pablo Andújar / Pedro Martinez → replaced by Pablo Andújar / Jaume Munar During the tournament André Göransson / Thiago Monteiro