Wayne Smith may refer to:
Politics
Wayne Smith (diplomat) (born 1932), U.S. diplomat who worked at the U.S. Embassy in Cuba Wayne Smith (Texas politician) (born 1943), member of the Texas House of Representatives Wayne Smith (Australian politician) (born 1952), member of the New South Wales Legislative Assembly
Sports
Wayne Smith (defensive back) (born 1957), National Football League, full name Wayne Lester Smith Wayne Smith (defensive lineman) (1950–2016), Canadian Football League Wayne Smith (offensive lineman) (born 1979), Canadian football, full name Wayne Anthony Smith Wayne Smith (rugby league) (born 1956), Australian rugby league player Wayne Smith (rugby union) (born 1957), New Zealand rugby coach and former rugby player Wayne Smith (ice hockey) (born 1943), NHL