William Frame was a Scottish footballer who played as a left back, although he could also play at left half. He spent six years with Clyde and six with Motherwell (being heavily involved during a period in the late 1920s where the Steelmen consistently finished near the top of the Scottish Football League table, being runners-up in the 1926–27 and 1929–30 seasons), before falling out of favour and serving a loan at second-tier Dunfermline Athletic. He then played in England's Football League for one year with Gateshead in 1931–32, followed by two seasons at Bray Unknowns in the Republic of Ireland and four seasons with Linfield in Northern Ireland, returning to Motherwell for a short spell in 1938. He did not score any goals in over 440 appearances in Scotland's leagues or the Scottish Cup.
During his time at Clyde, Frame played in the Glasgow FA's annual challenge match against Sheffield in four consecutive years, and he was a guest member of a squad organised by Third Lanark that toured South America in the summer of 1923.